![]() ![]() The primary toxicity concern is elevated serum calcium concentration which can lead to vascular and tissue calcification with subsequent damage to kidneys, blood vessels and the heart. Toxicity can include non-specific symptoms such as anorexia, weight loss, polyuria and heart arrhythmias. Vitamin D has many therapeutic benefits ranging from maintaining bone metabolism and strength to reducing the prevalence of colon cancer. ![]() In the case of vitamin D this risk/benefit ratio is skewed far in favor of benefits. To answer this question, we need to reflect on what is probably the most important principal of drug therapy which is, “the possible risks of therapy must outweigh its possible benefits.” Should elderly persons take a vitamin D supplement?
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